Childhood Brain Tumors
نویسنده
چکیده
Central nervous system (CNS) cancers are the second most frequent malignancy in childhood and the most common solid tumor in this age group. In recent years, significant advances in surgery, radiotherapy, and chemotherapy have favorably impacted survival for children with these tumors. However, a significant proportion of patients with CNS tumors suffer progress disease despite such treatment. Advances in the understanding the nature of the blood-brain/tumor barrier, chemotherapy resistance, tumor biology, and the role of angiogenesis and other signaling pathways in tumor progression and metastases have led to the advent of newer therapeutic strategies that circumvent these obstacles or target specific receptors that control signal transduction and/or angiogenesis in tumor cells. Ongoing clinical trials will determine if these novel modalities of treatment will improve the outcome of children with brain tumors.
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